Key Publications
McGhee, J.D. and J.D. Engel (1975) Subunit structure of chromatin is the same in plants and animals, Nature 254, 449-50.
Stalder, J., Groudine, M., Dodgson, J.B., Engel, J.D. and H. Weintraub (1980) Hb switching in chickens, Cell 19, 973-80.
Stalder, J., Larsen, A., Groudine, M., Dolan, M., Engel, J.D. and H. Weintraub (1980) Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNase I, Cell 20, 451-60.
Engel, J.D., Sugarman, B.J. and J.B. Dodgson (1982) A chicken histone H3 gene contains intervening sequences, Nature 297, 434-36.
McGhee, J.D., Dolan, M., Engel, J.D. and G. Felsenfeld (1982) A 200 base pair region at the 5′ end of the adult b-globin gene is accessible to nuclease digestion, Cell 27, 45-55.
Choi, O.-R. and J.D. Engel (1986) A 3′ enhancer is required for temporal and tissue-specific transcriptional activation of the chicken b-globin gene, Nature 323, 731-34.
Choi, O.-R. and J.D. Engel (1988) Developmental regulation of b-globin gene switching, Cell 55, 17-26.
Yamamoto, M., Ko, L.J., Leonard, M.W., Beug, H., Orkin, S.H. and J.D. Engel (1990) Activity and expression of the NF-E1 [GATA] multigene family, Genes and Development 4, 1650-1662.
Ko, L.J., M. Yamamoto, M.W. Leonard, K.M. George, P. Ting and J.D. Engel (1991) T lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T cell receptor d- gene enhancer, Molecular and Cellular Biology 11, 2778-84. PMCID: 360054
Lim, K.-C., Briegel, K., Plank, C., Beug, H., Engel, J.D. and M. Zenke (1993) Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroblast differentiation in a hormone-dependent manner, Genes and Development 7, 1097-1109.
Pandolfi, P.P., Roth, M.E., Karis, A., Leonard, M.W., Dzierzak, E., Grosveld, F., Engel, J.D., and M. H. Lindenbaum (1995) Targeted disruption of the Gata3 gene causes severe abnormalities in the nervous system and fetal liver haematopoiesis, Nature Genetics 11, 40-4.
Bungert, J., Davé, U., Lim, K.-C., Lieuw, K. H., Shavit, J. A., Liu, Q. and J.D. Engel (1995) Synergistic regulation of human b-globin gene switching by locus control region elements HS3 and HS4, Genes and Development 9, 3083-96.
Tanimoto, K., Bungert, J., Liu, Q., and J.D. Engel (1999) Effects of altered gene order or orientation of the locus control region on human b-globin gene expression in mice, Nature 398, 344-349.
Lim, K.-C., Lakshmanan, G., Crawford, S. E., Gu, Y., Grosveld, F. and J.D. Engel (2000) Gata3 gene ablation results in embryonic lethality as a consequence of sympathetic nervous system-specific catecholamine deficiency, Nature Genetics 25, 209-12.
Tanimoto, K., Liu, Q., Grosveld, F., Bungert, J. and J.D. Engel (2000) Context-dependent EKLF responsiveness defines the developmental specificity of the human e-globin gene in erythroid cells of YAC transgenic mice, Genes and Development 14, 2778-94. PMCID: 317038
Motohashi, H., Katsuoka, F., Shavit, J., Engel, J.D. and M. Yamamoto (2000) Positive or negative MARE-dependent transcriptional activation is determined by the abundance of small Maf proteins, Cell 103, 865-75.
Tanabe, O., Katsuoka, F., Campbell, A.D., Song, W., Yamamoto, M., Tanimoto, K. and J.D. Engel (2002) A candidate erythroid embryonic/fetal globin gene repressor contains a nuclear orphan receptor TR2/TR4 heterodimer, EMBO Journal 21, 3434-42. PMCID: 126089
Moriguchi, T., Takako, N., Hamada, M., Maeda, A., Fujioka, Y., Kuroha, T., Huber, R.E., Hasegawa, S.E., Takahashi, S., Lim, K.-C. and J.D. Engel (2006) GATA-3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation, Development 133, 3871-81. PMID: 16943277
Khandekar, M., Brandt, W., Zhou, Y., Dagenais, S., Glover, T., Suzuki, N., Shimizu, R., Yamamoto, M., Lim, K.-C. and J.D. Engel (2007) A Gata2 intronic enhancer confers its pan-endothelia-specific regulation, Development 134, 1703-12. PMID: 17395646
Tanabe, O., Shen, Y., Kobayashi, S., McPhee, D., Brandt, W., Jiang, X., Campbell, A.D., Chen, Y.-T., Chang, C., Yamamoto, M., Tanimoto, K. and J.D. Engel (2007) Developmental stage-specific, gene-selective repression of the embryonic and fetal b-type globin genes by the orphan nuclear receptors TR2 and TR4, EMBO Journal 26, 2295-306. PMCID: 1864974
Tanabe, O., Shen, Y., Liu, Q., Campbell, A., Kuroha, T., Yamamoto, M. and J.D. Engel (2007) The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription, Genes and Development 21, 2832-44. PMCID: 2045135
Hosoya, T., Kuroha, T., Moriguchi, T., Cummings, D., Maillard, I., Lim, K.-C. and J.D. Engel (2009) GATA-3 is required for early T lineage progenitor development, Journal of Experimental Medicine 206, 2987-3000. PMCID: PMC2806453
Campbell, A., Cui, S., Shi, L., Urbonya, R., Mathias, A., Bradley, K., Bonsu, K.O., Douglas, R., Halford, B., Schmidt, L. Harro, D., Gaicherio, D., Tanimoto, K., Tanabe, O. and J.D. Engel (2011) Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes, Proceedings of the National Academy of Sciences USA 108, 18,808-13. PMCID: PMC3219144
Lim, K.-C, Brandt, W., Ku, C-J, Hosoya-Ohmura, S., Camper, S., Yamamoto, M., Hosoya, T. and J.D. Engel (2012) A Gata2 vascular endothelial enhancer is required for the generation of hematopoietic stem cells, J. Clinical Investigation 122, 3705-17. PMCID: PMC3461906
Shi, L., Cui, S. Engel, J.D. and Tanabe, O (2013) Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction, Nature Medicine 19, 291-4.
Yamazaki, H., Suzuki, M., Otsuki, A., Shimizu, R., Bresnick, E.H., Engel, J.D. and M. Yamamoto (2014) A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression, Cancer Cell 25, 415-27. PMCID: PMC4012341.
Shi, L., Lin, Y.-H., Sierant, M.C., Zhu, F., Cui, S., Guan, Y., Sartor, M.A., Tanabe, O., Lim, K.-C., and J.D. Engel (2014) Developmental transcriptome analysis of human erythropoiesis, Human Molecular Genetics 23, 4528-42. PMCID: PMC4119405.
Cui, S., Tanabe, O., Sierant, M., Shi, L., Campbell, A.D., Lim, K.-C., and J.D. Engel (2015) Conditional compound loss of function of nuclear receptors Tr2 and Tr4 leads to robust induction of murine embryonic -type globin genes, Blood 125, 1477-87.
Ku, C.-J., Lim, K.-C., Kalantry, S., Maillard, I., Engel, J.D. and T. Hosoya (2015) A mono- to biallelic T cell transcriptional switch regulates GATA3 abundance, Genes and Development 29, 1930-41.
Ohmura, S., Mizuno, S., Oishi, H., Ku, C.J., Hosoya, T., Takahashi, S. and J.D. Engel (2016) A Gata3 T cell enhancer mediates transcription through TCF-1, HEB and RBPJ, J. Clinical Investigation 126, 865-78.
Katayama, S., Suzuki, M., Yamaoka, A., Keleku-Lukwete, N., Katsuoka, F., Otsuki, A., Kure, S., Engel, J.D. and M. Yamamoto (2017) GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis, Blood 130, 908-19. PMID: 28630119
Hosoya, T., D’Oliveira Albanus, R., Hensley, R., Myers, G., Kyono, Y., Kitzman, J., Parker, S. and J.D. Engel (2018) Global dynamics of stage-specific transcription factor binding during thymocyte development, Scientific Reports 8, 5605.
Hosoya, T., Li, H., Ku, C.-J., Wu, Q., Guan, Y and J.D. Engel (2018) High throughput single cell sequencing of both T cell receptor beta alleles, J. Immunology 201, 3465-70.
Liu, J., Tong, J., Gao, J., Guo, Q., Zhang, L., Wang, B., Zhao, H., Wang, H., Jiang, E., Kurita, R., Nakamura, Y., Tanabe, O., Engel, J.D., Bresnick, E, Zhou, J. and L. Shi (2018) Long Non-Coding RNA-Dependent Mechanism to Regulate Heme Biosynthesis and Erythrocyte Development, Nature Communications 22, 4386.
Yu, L., Jearawiriyapaisarn, N., Lee, M.P., Hosoya, T., Wu, Q., Myers, G., Lim, K.-C., Kurita, R., Nakamura, Y., Vojtek, A., Rual, J.-F. and J.D. Engel (2018) BAP1 deubiquitinase is a potent repressor of fetal hemoglobin synthesis, Genes and Development 32, 1537-49.
List of your publications and a link to the PubMed page.